Premium
CD34‐reactive trichodiscoma
Author(s) -
Chartier Molly,
Reed Michael L.,
Mandavilli Srinivas,
Fung Maxwell,
M. GrantKels Jane,
Murphy Michael
Publication year - 2004
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.0303-6987.2004.00202.x
Subject(s) - cd34 , pathology , desmin , immunohistochemistry , differential diagnosis , papule , mesenchyme , anatomy , biology , lesion , medicine , vimentin , epithelium , microbiology and biotechnology , stem cell
Background: Trichodiscomas are rare hamartomas of the dermal portion of the hair disc, a specialized component of the perifollicular mesenchyme. They are usually found as asymptomatic multiple skin‐colored papules on the face and extremities and may have an autosomal dominant inheritance pattern. However, a solitary variant has been described. Case report: A 78‐year‐old woman presented with a single, non‐pigmented, firm papule on the left tip of the nose, measuring 3.5 mm in diameter. Results: The histological examination revealed the previously described features of a trichodiscoma. The immunohistochemical analysis showed strong immunoreactivity for CD34 in the spindle cell component. Spindle cells were negative for S‐100, HMB‐45, Melan‐A, EMA, neurofilament, desmin, and Factor XIIIa by immunohistochemistry. Conclusions: We report strong reactivity for CD34 in the spindle cell component of a trichodiscoma. We suggest that this lesion be considered in the differential diagnosis of any CD34 + dermal spindle cell proliferation, in which an adjacent epithelial component cannot be entirely excluded.