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Photo‐distributed neutrophilic drug eruption and adult respiratory distress syndrome associated with antidepressant therapy
Author(s) -
Mecca Patricia,
Tobin Ellis,
Andrew Carlson J.
Publication year - 2004
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.0303-6987.2004.00155.x
Subject(s) - medicine , ards , drug eruption , antidepressant , respiratory distress , anxiolytic , drug , drug repositioning , lung , dermatology , pathology , anesthesia , pharmacology , anxiety , psychiatry
Drug reactions are well‐known complications of antidepressant therapy, often related to photosensitization. Herein is reported a singular case of antidepressant (amoxapine and citalopram) and anxiolytic related (perphenazine) photo‐distributed neutrophilic dermatosis and adult respiratory distress syndrome (ARDS). The clinicopathologic findings displayed overlapping features with drug‐induced Sweet's syndrome, acute generalized exanthematous pustulosis (AGEP), and so‐called sterile neutrophilic folliculitis with perifollicular vasculopathy. Of the three medications, only amoxapine has been associated with AGEP. Treatment with high‐dose systemic corticosteroids and cessation of drug therapy was followed by rapid resolution of the cutaneous eruption and respiratory distress. The possibility that neutrophil infiltration of the lung and/or accumulation of neutrophils in the skin and blood served as a source for reactive oxygen species, leading to lung injury and subsequent ARDS, is discussed.