Premium
Therapy with adjunctive doxycycline local delivery in patients with type 1 diabetes mellitus and periodontitis
Author(s) -
Martorelli de Lima Antonio Fernando,
Cury Cmila Cristina,
Palioto Daniela Bazan,
Duro Adhemar Mendes,
Silva Robert Carvalho da,
Wolff Larry F.
Publication year - 2004
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/j.0303-6979.2004.00576.x
Subject(s) - scaling and root planing , medicine , dentistry , placebo , doxycycline , chronic periodontitis , periodontitis , gingival recession , gingival and periodontal pocket , bleeding on probing , diabetes mellitus , type 2 diabetes mellitus , clinical trial , gastroenterology , endocrinology , antibiotics , alternative medicine , pathology , microbiology and biotechnology , biology
Objectives: The purpose of this study was to evaluate the effect of subgingival administration of doxycycline as an adjunct to periodontal therapy in type 1 diabetes mellitus (DM) patients. Material and methods: Twenty‐two paired periodontal defects 5.0 mm were treated in 11 patients (35–55 years old). After initial therapy the sites were randomly assigned into test (scaling and root planing+subgingival administration of 10% doxycycline hyclate gel) or control (scaling and root planing+subgingival placebo gel) groups. The clinical parameters of clinical attachment level (CAL), probing depth (PD) and gingival margin level (GML) for recession determination were assessed at baseline, after 6 weeks, and 6, 9 and 12 months, using a computerized probe. Data were statistically evaluated using Duncan and F tests. Results: Between study group comparisons indicated PD reduction and CAL gain were greater in the test group than in the control group at 6 weeks and 6, 9 and 12 months but only statistically significant at 12 months ( p <0.05). Within study group comparisons indicated statistically significant differences were found for CAL and PD values favouring the adjunctive doxycycline group from baseline to 6 weeks and 6, 9 and 12 months ( p <0.05). Conclusions: These findings suggest that subgingivally delivered doxycycline hyclate produces additional favorable clinical results to periodontal therapy in type 1 DM patients.