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Immunoglobulin Heavy‐Chain Receptor Editing is Observed in the NOD/SCID Model of Human B‐Cell Development
Author(s) -
Kolar G. R.,
Capra J. D.
Publication year - 2004
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.0300-9475.2004.01467.x
Subject(s) - antibody , biology , receptor , immunoglobulin heavy chain , gene , nod , immunoglobulin light chain , heavy chain , genome editing , immunology , computational biology , genetics , microbiology and biotechnology , crispr
Receptor editing and receptor revision are the two mechanisms of antibody diversity that result in either complete V‐gene replacement or the formation of hybrid V genes. We do not yet understand how this process unfolds, because they are rare and difficult to study in vivo . In this study, we describe a family of VH4‐34:VH4‐61 hybrids isolated from a human B‐cell chimeric non‐obese diabetic/severe combined immunodeficient mouse. The observation of hybrid immunoglobulin sequences in human B cells that developed in this model system makes it useful for the study of this mechanism of diversification and tolerance.