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The Receptor for Interleukin‐17E is Induced by Th2 Cytokines in Antigen‐Presenting Cells
Author(s) -
Gratchev A.,
Kzhyshkowska J.,
Duperrier K.,
Utikal J.,
Velten F. W.,
Goerdt S.
Publication year - 2004
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.0300-9475.2004.01443.x
Subject(s) - cytokine , biology , population , interleukin 4 , immunology , receptor , antigen , interleukin 15 , in vivo , interleukin , microbiology and biotechnology , medicine , biochemistry , genetics , environmental health
Interleukin‐17E (IL‐17E) (IL‐25) is a recently identified cytokine capable to induce Th2‐associated cytokine production (IL‐5 and IL‐13) and T helper 2 (Th2)‐type pathologies in animal models. The IL‐17E‐responsive cell population in vivo was described to be a further uncharacterized non‐T‐, non‐B‐splenic accessory cell. Despite the identification of IL‐17BR as the receptor for IL‐17E, the cell population expressing IL‐17BR has hitherto not been identified. Here, we show that human monocyte‐derived Th2‐skewed antigen‐presenting cells (APC2) express membrane‐bound and soluble forms of IL‐17BR on the mRNA and protein level upon stimulation with IL‐4, IL‐10, IL‐13 or transforming growth factor‐β in vitro . These results indicate that IL‐17BR‐expressing APC2s may mediate the development of the IL‐17E‐mediated immunological reaction patterns observed in vivo .