Premium
Phenotype and Natural Killer Cell Sensitivity of a Radiation‐Induced Acute T‐Cell Leukaemia (Roser Leukaemia) in PVG Rats
Author(s) -
Nestvold J.,
Stokland A.,
Naper C.,
Rolstad B.
Publication year - 2004
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.0300-9475.2004.01436.x
Subject(s) - in vitro , major histocompatibility complex , cell , in vivo , cd3 , t cell , biology , immunology , antigen , immune system , microbiology and biotechnology , cd8 , cancer research , biochemistry , genetics
A radiation‐induced T‐cell leukaemia [Roser leukaemia (RL)] in the rat was conditioned for growth in vitro by repeated in vivo – in vitro passages. This in vitro cell line, termed RL‐T, maintained its leukaemia‐inducing property when transferred to syngeneic PVG rats. It expresses several T‐cell markers and the T‐cell α/β receptor–CD3 complex. RL‐T, furthermore, expresses major histocompatibility complex (MHC) I antigens, both classical (RT1.A) and nonclassical (RT1.C), which makes it susceptible to killing by alloreactive natural killer cells in vitro .
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom