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Involvement of Interleukin‐1β in Systemic Morphine Effects on Paw Oedema in a Mouse Model of Acute Inflammation
Author(s) -
Pourpak Z.,
Ahmadiani A.,
Alebouyeh M.
Publication year - 2004
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.0300-9475.2004.01396.x
Subject(s) - morphine , carrageenan , (+) naloxone , medicine , inflammation , pharmacology , peripheral , anti inflammatory , cytokine , immune system , intraperitoneal injection , interleukin , immunology , opioid , receptor
Recent studies suggest that peripheral morphine may represent a valuable treatment in acute inflammatory painful diseases through peripheral or central mechanisms. In the present study, anti‐inflammatory effects of systemic morphine on carrageenan‐induced hind paw oedema were examined in a model of peripheral acute oedema in mice. Carrageenan induced a time‐dependent inflammation that was maximal 3 h after administration. While intraperitoneal administration of morphine sulfate at a low dose (1 mg/kg) increased carrageenan‐induced hind paw oedema, intraperitoneal injection of morphine sulfate at a high dose (7 mg/kg) resulted in significant anti‐inflammatory effects on carrageenan‐induced hind paw oedema. These anti‐inflammatory effects were blocked by pretreatment with naloxone. Measuring the serum levels of interleukin‐1β revealed that increases in serum levels of this cytokine were involved in morphine anti‐inflammatory effects. Pretreatment with naloxone decreased interleukin‐1β serum levels near to those of control group. In conclusion, these data demonstrate that morphine produced pro‐ or anti‐inflammatory effects in a dose‐dependent manner through peripheral or central mechanisms. The observed anti‐inflammatory effects may be due to an increase in the cytokine production and/or release by host immune systems.