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Activation by malaria antigens renders mononuclear cells susceptible to HIV infection and re‐activates replication of endogenous HIV in cells from HIV‐infected adults
Author(s) -
Froebel K.,
Howard W.,
Schafer J. R.,
Howie F.,
Whitworth J.,
Kaleebu P.,
Brown A. L.,
Riley E.
Publication year - 2004
Publication title -
parasite immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 75
eISSN - 1365-3024
pISSN - 0141-9838
DOI - 10.1111/j.0141-9838.2004.00701.x
Subject(s) - malaria , biology , virology , immunology , plasmodium falciparum , immune system , peripheral blood mononuclear cell , antigen , viral replication , virus , in vitro , biochemistry
SUMMARY We have tested the hypothesis that activation of T cells by exposure to malaria antigens facilitates both de novo HIV infection and viral reactivation and replication. PBMC from malaria‐naïve HIV‐uninfected European donors could be productively infected with HIV following in vitro stimulation with a lysate of Plasmodium falciparum schizonts and PBMC from malaria‐naïve and malaria‐exposed (semi‐immune) HIV‐positive adults were induced to produce higher levels of virus after stimulation with the same malaria extract. These findings suggest that effective malaria control measures might con‐tribute to reducing the spread of HIV and extending the life span of HIV‐infected individuals living in malaria endemic areas.