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An attempt to artificially select Strongyloides ratti for resistance to the host immune response
Author(s) -
Wilkes C. P.,
Viney M. E.
Publication year - 2004
Publication title -
parasite immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 75
eISSN - 1365-3024
pISSN - 0141-9838
DOI - 10.1111/j.0141-9838.2004.00683.x
Subject(s) - heligmosomoides polygyrus , biology , immune system , selection (genetic algorithm) , immunology , strongyloidiasis , host (biology) , reproduction , strongyloides , helminths , genetics , artificial intelligence , computer science
SUMMARY Previous work has selected Heligmosomoides polygyrus for increased survival and reproduction in hosts with prior exposure to H. polygyrus , and therefore ‘immune’ to this parasite. We investigated whether Strongyloides ratti would respond similarly to selection for survival and reproduction in S. ratti ‐immune hosts. During 32 generations of selection, there appeared to be an initial, brief response to this selection, but this was not sustained and, eventually, the immune‐selected line died out. Specific measures of the response to selection at generations 6, 12 and 25 did not detect any significant response to selection. Therefore, we have failed to select a line of S. ratti for increased resistance to its host immune response.