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Origin and functional heterogeneity of non‐lymphoid tissue dendritic cells in mice
Author(s) -
Helft Julie,
Ginhoux Florent,
Bogunovic Milena,
Merad Miriam
Publication year - 2010
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/j.0105-2896.2009.00885.x
Subject(s) - biology , lymphatic system , immunology , lymphopoiesis , function (biology) , immunity , dendritic cell , homeostasis , follicular dendritic cells , cell lineage , microbiology and biotechnology , immune system , cellular differentiation , haematopoiesis , stem cell , t cell , antigen presenting cell , genetics , gene
Summary: Dendritic cells (DCs) have been extensively studied in mice lymphoid organs, but less is known about the origin and the mechanisms that regulate DC development and function in non‐lymphoid tissues. Here, we discuss recent evidence establishing the contribution of the DC‐restricted lineage to the non‐lymphoid tissue DC pool and discuss the mechanisms that control the homeostasis of non‐lymphoid tissue DCs. We also review recent results underlining the functional specialization of tissue DCs and discuss the potential implications of these findings in tissue immunity and in the development of novel vaccine strategies.