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Syk‐coupled C‐type lectin receptors that mediate cellular activation via single tyrosine based activation motifs
Author(s) -
Kerrigan Ann M.,
Brown Gordon D.
Publication year - 2010
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/j.0105-2896.2009.00882.x
Subject(s) - immunoreceptor tyrosine based activation motif , c type lectin , biology , syk , endocytic cycle , microbiology and biotechnology , dc sign , tyrosine , receptor , pattern recognition receptor , signal transducing adaptor protein , signal transduction , dendritic cell , innate immune system , tyrosine kinase , antigen , immunology , biochemistry , endocytosis
Summary: Different dendritic cell (DC) subsets have distinct specialized functions contributed in part by their differential expression of pattern recognition receptors (PRRs). C‐type lectin receptors (CLRs) are a group of PRRs expressed by DCs and other myeloid cells that can recognize endogenous ligands as well as a wide range of exogenous structures present on pathogens. Dual roles in homeostasis and immunity have been demonstrated for some members of this receptor family. Largely due to their endocytic ability and subset specific expression, DC‐expressed CLRs have been the focus of significant antigen‐targeting studies. A number of CLRs function on the basis of signaling via association with immunoreceptor tyrosine‐based activation motif (ITAM)‐containing adapter proteins. Others contain ITAM‐related motifs or immunoreceptor tyrosine‐based inhibitory motifs (ITIMs) in their cytoplasmic tails. Here we review CLRs that induce intracellular signaling via a single tyrosine‐based ITAM‐like motif and highlight their relevance in terms of DC function.