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Microbe–dendritic cell dialog controls regulatory T‐cell fate
Author(s) -
Grainger John R.,
Hall Jason A.,
Bouladoux Nicolas,
Oldenhove Guillaume,
Belkaid Yasmine
Publication year - 2010
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/j.0105-2896.2009.00880.x
Subject(s) - biology , dialog box , cell fate determination , dendritic cell , cell , microbiology and biotechnology , computational biology , immunology , genetics , immune system , transcription factor , gene , computer science , world wide web
Summary: Each microenvironment is controlled by a specific set of regulatory elements that have to be finely and constantly tuned to maintain local homeostasis. These environments could be site specific, such as the gut environment, or induced by chronic exposure to microbes. Various populations of dendritic cells are central to the orchestration of this control. In this review, we discuss some new findings associating dendritic cells from defined compartments with the induction and control of regulatory T cells in the context of exposure to both commensal and pathogenic microbes.