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Development and functional specialization of CD103 + dendritic cells
Author(s) -
Del Rio MariaLuisa,
Bernhardt Günter,
RodriguezBarbosa JoseIgnacio,
Förster Reinhold
Publication year - 2010
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/j.0105-2896.2009.00874.x
Subject(s) - biology , immunology , foxp3 , homing (biology) , microbiology and biotechnology , immune system , cd8 , population , chemokine receptor , integrin , receptor , chemokine , medicine , ecology , environmental health , biochemistry
Summary: CD103 (α E ) integrin expression distinguishes a population of dendritic cells (DCs) that can be found in many if not all lymphoid and non‐lymphoid organs. CD103 + DCs display distinct functional activities. Migratory CD103 + DCs derived from skin, lung, and intestine efficiently present exogenous antigens in their corresponding draining lymph nodes to specific CD8 + T cells through a mechanism known as cross‐presentation. On the T cells they prime, intestinal CD103 + DCs can drive the induction of the chemokine receptor CCR9 and α 4 β 7 integrin, both known as gut‐homing receptors. CD103 + DCs also contribute to control inflammatory responses and intestinal homeostasis by fostering the conversion of naive T cells into induced Foxp3 + regulatory T cells, a mechanism that relies on transforming growth factor‐β and retinoic acid signaling. This review discusses recent findings that identify murine CD103 + DCs as important regulators of the immune response.