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The U1‐snRNP complex: structural properties relating to autoimmune pathogenesis in rheumatic diseases
Author(s) -
Kattah Nicole H.,
Kattah Michael G.,
Utz Paul J.
Publication year - 2010
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/j.0105-2896.2009.00863.x
Subject(s) - snrnp , autoimmunity , small nuclear ribonucleoprotein , immunology , ribonucleoprotein , biology , epitope , autoantibody , immunogenicity , immune system , autoimmune disease , rna , antigen , genetics , antibody , gene
Summary: The U1 small nuclear ribonucleoprotein particle (snRNP) is a target of autoreactive B cells and T cells in several rheumatic diseases including systemic lupus erythematosus (SLE) and mixed connective tissue disease (MCTD). We propose that inherent structural properties of this autoantigen complex, including common RNA‐binding motifs, B and T‐cell epitopes, and a unique stimulatory RNA molecule, underlie its susceptibility as a target of the autoimmune response. Immune mechanisms that may contribute to overall U1‐snRNP immunogenicity include epitope spreading through B and T‐cell interactions, apoptosis‐induced modifications, and Toll‐like receptor (TLR) activation through stimulation by U1‐snRNA. We conclude that understanding the interactions between U1‐snRNP and the immune system will provide insights into why certain patients develop anti‐U1‐snRNP autoimmunity, and more importantly how to effectively target therapies against this autoimmune response.