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The role of the transcription factor Foxp3 in the development of regulatory T cells
Author(s) -
Kim Jeong M.,
Rudensky Alexander
Publication year - 2006
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/j.0105-2896.2006.00426.x
Subject(s) - foxp3 , biology , transcription factor , regulatory t cell , forkhead transcription factors , autoimmunity , adoptive cell transfer , t cell , t cell receptor , microbiology and biotechnology , immunology , genetics , il 2 receptor , immune system , gene
Summary: Early studies of mice subjected to neonatal thymectomy and analyses of adoptive T‐cell transfer into lymphopenic hosts led to the identification of a specialized subset of regulatory CD4 + T cells capable of suppressing various manifestations of autoimmunity. Recently, a combination of genetic, molecular, and traditional cellular approaches provided novel powerful means to investigate the biology of these cells. Here, we review earlier and current work from our laboratory, establishing a dedicated function for the transcription factor Foxp3 in the process of regulatory T‐cell lineage commitment and a role for TCR‐ and cytokine‐mediated signals in regulation of Foxp3 expression.