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The role of CD28 and cytotoxic T‐lymphocyte antigen‐4 (CTLA‐4) in regulatory T‐cell biology
Author(s) -
Sansom David M.,
Walker Lucy S. K.
Publication year - 2006
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/j.0105-2896.2006.00419.x
Subject(s) - cytotoxic t cell , cd28 , ctla 4 , biology , immunology , t cell , microbiology and biotechnology , regulatory t cell , antigen , population , t lymphocyte , immune system , il 2 receptor , genetics , in vitro , medicine , environmental health
Summary: The profound influence of CD28 and cytotoxic T‐lymphocyte antigen‐4 (CTLA‐4) on T‐cell immunity has been known for over a decade, yet the precise roles played by these molecules still continue to emerge. Initially viewed as molecules that provide cell‐intrinsic costimulatory and inhibitory signals, recent evidence suggests that both CD28 and CTLA‐4 are also important in the homeostasis and function of a population of suppressive cells, termed regulatory T cells (Tregs). Here we review the main features of the CD28 and CTLA‐4 system and examine how these impact upon Treg biology.