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Natural regulatory T cells and parasites: a common quest for host homeostasis
Author(s) -
Belkaid Yasmine,
Blank Rebecca B.,
Suffia Isabelle
Publication year - 2006
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/j.0105-2896.2006.00409.x
Subject(s) - biology , effector , host (biology) , immunology , immune system , population , natural killer cell , genetics , cytotoxic t cell , medicine , environmental health , in vitro
Summary: This review discusses the roles played by natural CD4 + CD25 + regulatory T cells (natural Tregs) during parasitic infections. Natural Tregs may limit the magnitude of effector responses, which may result in failure to adequately control infection. However, natural Tregs also help to limit collateral tissue damage caused by vigorous antimicrobial immune responses. We discuss the hypothesis that parasites have evolved means to manipulate the host's natural Treg population, thereby generating conditions that secure survival in their vertebrate host for an extended period of time.