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The use of genomewide ENU mutagenesis screens to unravel complex mammalian traits: identifying genes that regulate organ‐specific and systemic autoimmunity
Author(s) -
Hoyne Gerard F.,
Goodnow Christopher C.
Publication year - 2006
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/j.0105-2896.2006.00363.x
Subject(s) - biology , autoimmunity , gene , genetics , mutagenesis , immune system , phenotype , computational biology , genetic screen , mutation
Summary: T‐cell development is perhaps one of the best understood processes of mammalian cell differentiation, as many of the genes and pathways have been identified. By contrast, relatively little is known about the genes and pathways involved in immunological tolerance to self‐antigens. Here, we describe the challenges associated with a genomewide screen designed at identifying new immune regulatory genes that uses a model of organ‐specific autoimmunity leading to type 1 diabetes. The successful propagation and identification of the new gene variants will shed light on the various developmental checkpoints in lymphocyte development that are crucial for establishing tolerance to self‐antigens.