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Turning down the system: counter‐regulatory mechanisms in bone and adaptive immunity
Author(s) -
Wein Marc N.,
Jones Dallas C.,
Glimcher Laurie H.
Publication year - 2005
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/j.0105-2896.2005.00322.x
Subject(s) - biology , acquired immune system , transcription factor , effector , immune system , microbiology and biotechnology , regulation of gene expression , immunity , computational biology , gene , immunology , genetics
Summary: Major advances have been made in recent years toward the identification of transcription factors that control cell‐type‐specific gene expression in the skeletal and adaptive immune systems. However, the identification of factors necessary and sufficient to drive production of effector cell proteins such as matrix components and cytokines represents the first step toward understanding how cells in bone and the adaptive system achieve their highly specialized functions. Here, we provide selected examples of counter‐regulatory mechanisms that serve to turn down cells involved in extracellular matrix biosynthesis and adaptive immunity at the level of the transcription factors Runx2 and nuclear factor for the activation of T cells.