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All the peptides that fit: the beginning, the middle, and the end of the MHC class I antigen‐processing pathway
Author(s) -
Shastri Nilabh,
Cardinaud Sylvain,
Schwab Susan R.,
Serwold Thomas,
Kunisawa Jun
Publication year - 2005
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/j.0105-2896.2005.00321.x
Subject(s) - antigen processing , major histocompatibility complex , biology , mhc class i , mhc restriction , endoplasmic reticulum , antigen , microbiology and biotechnology , cytoplasm , transporter associated with antigen processing , cd8 , antigen presentation , ribosome , t cell , biochemistry , immune system , genetics , rna , gene
Summary: The end result of the antigen‐processing pathway is the display of peptide‐bound major histocompatibility complex I (pMHC I) molecules. The pMHC I molecules are expressed on the cell surface where they can be surveyed by CD8 + T cells for abnormal proteins. MHC I molecules present a large repertoire of peptides that fit perfectly in their binding grooves and represent the otherwise hidden intracellular contents. Many peptides originate as defective ribosomal products in the cytoplasm. In a stepwise manner, the antigen‐processing pathway generates and protects the proteolytic intermediates until they yield the final peptides that can fit the MHC I in the endoplasmic reticulum.