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Phagocytosis: the convoluted way from nutrition to adaptive immunity
Author(s) -
Desjardins Michel,
Houde Mathieu,
Gag Etienne
Publication year - 2005
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/j.0105-2896.2005.00319.x
Subject(s) - phagosome , biology , phagocytosis , acquired immune system , immunity , innate immune system , immune system , microbiology and biotechnology , dictyostelium , organelle , intracellular , immunology , genetics , gene
Summary: Phagocytosis, the process by which cells internalize large particulate materials from their milieu and sequester them in phagosomes, plays a role in a variety of cell functions ranging from nutrition in ameba to innate and adaptive immunity in mammals. Recent findings revealed unexpected characteristics of phagosomes, highlighting how this complex organelle may have evolved, from Dictyostelium to human, to become a key player in our ability to mount an efficient immune response against a variety of intracellular pathogens.