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Tolerance‐induced receptor selection: scope, sensitivity, locus specificity, and relationship to lymphocyte‐positive selection
Author(s) -
AïtAzzouzene Djemel,
Skog Patrick,
Retter Marc,
Kouskoff Valerie,
Hertz Marc,
Lang Julie,
Kench Jennifer,
Chumley Michael,
Melamed Doron,
Sudaria Janice,
Gavin Amanda,
Martensson Annica,
Verkoczy Laurent,
Duong Bao,
Vela José,
Nemazee David
Publication year - 2004
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/j.0105-2896.2004.0106.x
Subject(s) - biology , clonal deletion , t cell receptor , central tolerance , lymphocyte , b cell , negative selection , receptor , genetics , immune tolerance , antigen , locus (genetics) , gene , immunology , antibody , microbiology and biotechnology , t cell , immune system , genome
Summary: Receptor editing is a mode of immunological tolerance of B lymphocytes that involves antigen‐induced B‐cell receptor signaling and consequent secondary immunoglobulin light chain gene recombination. This ongoing rearrangement often changes B‐cell specificity for antigen, rendering the cell non‐autoreactive and sparing it from deletion. We currently believe that tolerance‐induced editing is limited to early stages in B‐cell development and that it is a major mechanism of tolerance, with a low‐affinity threshold and the potential to take place in virtually every developing B cell. The present review highlights the contributions from our laboratory over several years to elucidate these features.