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Interleukin‐10 in viral diseases and cancer: exiting the labyrinth?
Author(s) -
Vicari Alain P.,
Trinchieri Giorgio
Publication year - 2004
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/j.0105-2896.2004.00216.x
Subject(s) - cancer , biology , immunology , interleukin , cytokine , genetics
Summary: Interleukin‐10 (IL‐10) is unique among cytokines, as it is considered both as a potent immunostimulatory and immunosuppressive factor. This complex biology has been particularly challenging when trying to define the useful or harmful role of IL‐10 in chronic viral diseases and cancer. In the present review, we emphasize how these multiple roles define IL‐10 as an adaptive molecule, constantly tuning the host response against dangerous and resourceful pathogens.