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The role of type I interferons in non‐viral infections
Author(s) -
Bogdan Christian,
Mattner Jochen,
Schleicher Ulrike
Publication year - 2004
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/j.0105-2896.2004.00207.x
Subject(s) - biology , immunology , alpha interferon , beta (programming language) , alpha (finance) , interferon type i , in vivo , virology , interferon beta , pathogenesis , interferon , in vitro , function (biology) , medicine , genetics , construct validity , nursing , patient satisfaction , computer science , programming language
Summary: For a long time, the family of type I interferons (IFN‐α/β) has received little attention outside the fields of virology and tumor immunology. In recent years, IFN‐α/β regained the interest of immunologists, due to the phenotypic and functional characterization of IFN‐α/β‐producing cells, the definition of novel immunomodulatory functions and signaling pathways of IFN‐α/β, and the observation that IFN‐α/β not only exerts antiviral effects but is also relevant for the pathogenesis or control of certain bacterial and protozoan infections. This review summarizes the current knowledge on the production and function of IFN‐α/β during non‐viral infections in vitro and in vivo .