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Sibling rivalry: competition between Pol X family members in V(D)J recombination and general double strand break repair
Author(s) -
Nick McElhinny Stephanie A.,
Ramsden Dale A.
Publication year - 2004
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/j.0105-2896.2004.00160.x
Subject(s) - biology , v(d)j recombination , genetics , polymerase , non homologous end joining , dna , recombination , homologous recombination , microbiology and biotechnology , gene
Summary: The nonhomologous end‐joining pathway is a major means for repairing double‐strand breaks (DSBs) in all mitotic cell types. This repair pathway is also the only efficient means for resolving DSB intermediates in V(D)J recombination, a lymphocyte‐specific genome rearrangement required for assembly of antigen receptors. A role for polymerases in end‐joining has been well established. They are a major factor in determining the character of repair junctions but, in contrast to ‘core’ end‐joining factors, typically appear to have a subtle impact on the efficiency of end‐joining. Recent work implicates several members of the Pol X family in end‐joining and suggests surprising complexity in the control of how these different polymerases are employed in this pathway.