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Allergic contact dermatitis from timolol and dorzolamide eye drops
Author(s) -
Kalavala M.,
Statham B. N.
Publication year - 2006
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.0105-1873.2006.0645b.x
Subject(s) - dorzolamide , timolol , medicine , dermatology , allergic contact dermatitis , eye drop , contact dermatitis , ophthalmology , allergy , anesthesia , glaucoma , immunology
A 61-year-old man presented with a solitary ulcerated plaque below the right eye, which had been gradually increasing in size for 8 months. On examination, there was a 1-cm diameter ulcer with a rolled edge inferiorly, and a clinical diagnosis of basal cell carcinoma was made (Fig. 1). An incision biopsy from the rolled edge showed non-specific inflammation, so a second biopsy was taken from a different area to rule out a sampling error. This showed an acute inflammatory infiltrate within the epidermis with acanthosis and a more chronic infiltrate within the dermis. The patient was then referred for patch tests, which demonstrated a strongly positive (+++) reaction to nickel. Examination of the patient’s spectacles revealed that the gold plating on the right side had worn off on the rim which rested on the ulcerated area on his cheek. The dimethylglyoxime spot test from the worn area was strongly positive for nickel but was negative from where the gold plating remained on his spectacles (Fig. 2).