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Cross‐reactivity between thiurams
Author(s) -
Lerbæk Anne,
Menné Torkil,
Knudsen Bodil
Publication year - 2006
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.0105-1873.2006.00785.x
Subject(s) - sensitization , reactivity (psychology) , cross reactivity , allergic contact dermatitis , allergen , chemistry , contact dermatitis , concomitant , allergy , cross reactions , immunology , medicine , pathology , antigen , alternative medicine
Retesting with an allergen at a site with previous allergic contact dermatitis has been shown to enhance reactivity. It has been suggested that retesting with a cross‐reactive allergen will also induce hyperreactivity. Concurrent sensitization to more than 1 thiuram is common, but whether this is due to concomitant primary sensitization or cross‐reactivity is uncertain. The aim of this study was to investigate the use of retesting to distinguish between concomitant sensitization and cross‐reactivity in the rubber chemicals tetraethylthiuram disulphide (TETD) and tetramethylthiuram disulphide (TMTD). There was a non‐significant trend towards enhanced reactivity for both TETD and TMTD when testing in an area with previous allergic contact dermatitis due to TETD. Cross‐reactivity between the 2 chemicals is likely, but a definite conclusion from this pilot study is not possible.