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Systemic contact dermatitis after oral exposure to nickel: a review with a modified meta‐analysis
Author(s) -
Jensen Christian Stab,
Menné Torkil,
Duus Johansen Jeanne
Publication year - 2006
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.0105-1873.2006.00773.x
Subject(s) - contact dermatitis , nickel , meta analysis , medicine , nickel allergy , dermatology , immunology , allergy , materials science , metallurgy
Systemic contact dermatitis can be elicited experimentally in nickel‐sensitive individuals by oral nickel exposure. A crucial point interpreting such experiments has been the relevance of nickel exposure from drinking water and diet. The aim of this meta‐analysis study on former nickel‐exposure investigations was to provide the best possible estimation of threshold values of nickel doses that may cause systemic contact dermatitis in nickel‐sensitive patients. 17 relevant investigations were identified, and statistical analyses were performed in a stepwise procedure. 9 studies were included in the final dose–response analysis, which divided the studies into a homogenous middle group of 5 studies and 2 groups of 2 studies with a higher and lower response frequency, respectively, described by logistic dose–response curves shifted in parallel. On the basis of these curves, calculations were made of the doses that, theoretically, would cause systemic contact dermatitis in exposed nickel‐sensitive patients. The results from the 2 most sensitive groups show that 1% of these individuals may react with systemic contact dermatitis at normal daily nickel exposure from drinking water and diet, i.e. 0.22–0.35 mg nickel.