Premium
Photoallergic contact dermatitis from ketoprofen in southern Sweden
Author(s) -
Hindsén Monika,
Zimerson Erik,
Bruze Magnus
Publication year - 2006
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.0105-1873.2005.00778.x
Subject(s) - ketoprofen , contact dermatitis , dermatology , allergic contact dermatitis , medicine , contact allergy , allergy , pharmacology , immunology
The non‐steroidal anti‐inflammatory drug ketoprofen is widely used for topical treatment. In Sweden, ketoprofen has been available for topical application since 1995. Photoallergic contact dermatitis from ketoprofen‐containing topical preparations usually includes severe eczematous reactions. Ketoprofen is derived from propionic acid, and it is also a substituted benzophenone and therefore structurally similar to fenofibrate and sunscreen agents based on benzophenones. During the last 2 years, 35 patients have been refereed to our department with suspected photoallergic or allergic reactions after having used ketoprofen‐containing gels. Photopatch testing with the photopatch standard series, the ketoprofen‐containing gels and their ingredients, fenofibrate, benzophenone‐3, benzophenone‐10 and benzophenone‐4, was performed. Photoallergic reactions to ketoprofen were noted in 35 patients and a simultaneous contact allergy to ketoprofen in 2 patients. Simultaneous photoallergy to fentichlor, tetrachlorosalicylanilide and fenofibrate was registered in 74%, 40% and 73% of the patients, respectively.