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Recommendation to include methyldibromo glutaronitrile in the European standard patch test series
Author(s) -
Bruze Magnus,
Goossens An,
Gruvberger Birgitta
Publication year - 2005
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.0105-1873.2005.00482.x
Subject(s) - patch test , contact allergy , allergic contact dermatitis , contact dermatitis , medicine , patch testing , dermatology , european standard , allergy , irritant contact dermatitis , surgery , immunology , architectural engineering , engineering
The preservative methyldibromo glutaronitrilc (MDBGN) is used non‐occupationally and occupationally. High contact allergy rates have been reported when tested in consecutive dermatitis patients as well as clinical cases with allergic contact dermatitis. Up till now there has been no agreement on which patch test preparation to use to trace contact allergy to MDBGN. From the year 2005 on, MDBGN at 0.5% w/w in petrolatum is recommended for the European standard patch test series. The choice of 0.5% is based on consideration of rates of contact allergy, doubtful and irritant reactions, as well as on information on clinical relevance represented by results of a repeated open application test, and patch test concentrations to diagnose allergic contact dermatitis from MDBGN in individual cases.