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Patch test reactivity to nickel sulphate and fragrance mix in unselected children
Author(s) -
Jøhnke Hanne,
Norberg LA,
Vach W,
BindslevJensen C,
Høst A,
Andersen KE
Publication year - 2004
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.0105-1873.2004.0309x.x
Subject(s) - patch test , medicine , patch testing , reactivity (psychology) , nickel allergy , population , nickel , contact dermatitis , erythema , dermatology , allergy , pediatrics , immunology , chemistry , pathology , environmental health , organic chemistry , alternative medicine
Objectives: Study patch test reactivity to nickel sulphate and fragrance mix in a population of unselected infants with focus on reproducibility, clinical relevance, and nickel patch test concentration. Method: The data presented is part of a clinical epidemiological study of allergic diseases in newborns followed prospectively with questionnaire, clinical examination and testing at 0, 3, 6, 12 and 18 months of age. TRUE Test patches were used with nickel sulphate in 3 concentrations: 200, 66, 22 ìg/cm 2 and fragrance mix 430 ìg/cm 2 . A positive reaction suggesting sensitisation was defined as at least palpable erythema present at both the 12 and 18 months follow‐up visits. Results: A total of 543 children (268 girls, 275 boys) were patch tested at least once, 304 children were tested at both 12 and 18 months. The prevalence of a reproducible positive reaction to nickel sulphate 200 ìg/cm 2 was 8.6%(20 girls, 6 boys). A transient reactivity was observed in 111 children (53 girls, 58 boys). A clinical relevance to nickel was found in only one child. There was no association between number of patch test procedures performed and reactions to nickel sulphate. Reproducible reactivity to fragrance mix was not found. Conclusion: A high proportion of transient patch test reactivity to nickel sulphate 200 ìg/cm 2 was found. Patch testing with nickel in concentrations used for adults cannot be recommended in infants. The interpretation of a singular positive nickel patch test in small children must be assessed with caution. Allergic reactions to fragrance mix were not found in this age group.