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A 10‐rear review to determine whether exposure to p‐phenylenediamine during patch tests leads to sensitisation
Author(s) -
Dawe Simon,
White I,
Ryecroft R,
McFadden J
Publication year - 2004
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.0105-1873.2004.0309p.x
Subject(s) - patch test , medicine , patch testing , european standard , p phenylenediamine , population , allergic contact dermatitis , dermatology , atopic dermatitis , skin test , contact dermatitis , surgery , allergy , immunology , pathology , tuberculosis , architectural engineering , materials science , environmental health , engineering , composite material
Our review aimed to answer the question of whether exposure to PPD in the European standard series could lead to subsequent sensitisation in a significant number of patients. We aimed to achieve this by comparing the frequency of PPD sensitivity in patients who had never been patch tested compared to those who were having repeat patch testing and who therefore had been exposed to PPD in patch test conditions. From January 1990 to December 1999 14,001 patient’s with suspected contact dermatitis were tested with the European standard series in St. Johns. We selected and obtained the records of all patient’s during this time period who had a positive patch test to PPD free base 1% pet. Of the 14,001 patient’s tested, 1035 had previously been patch tested on at least one occasion representing 7.4% of the population. This proportion varied from 5.6% in 1994 to 11.1% in 1991 but there was no obvious trend during the ten year period. The total number of PPD positive reactions (+ to +++) over the ten year period in the whole population was 449 (3.2%). The number of PPD positive reactions in the first time testers was 419 (3.2%) compared to 30 (2.9)% in the repeat testers. Our figures over a ten‐year period do not show an increase in the rate of PPD sensitivity in patients who have been previously patch tested. These figures suggest that PPD 1% pet. as used in the standard series is not actively sensitising patients who are repeatedly patch tested.