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Mouse models of skin autoimmunity and peripheral tolerance
Author(s) -
Katz Stephen I
Publication year - 2004
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.0105-1873.2004.0309j.x
Subject(s) - ovalbumin , peripheral tolerance , genetically modified mouse , immunology , autoimmunity , cd8 , transgene , clonal deletion , central tolerance , peripheral , immune tolerance , self tolerance , biology , ratón , microbiology and biotechnology , antigen , t cell , immune system , t cell receptor , medicine , genetics , gene
To understand the mechanisms involved in immunological tolerance to skin‐associated proteins, we have developed trangenic (Tg) mice that express a model self antigen, membrane‐bound chicken ovalbumin (OVA), under the control of a keratin 14 (K14) promoter. We have characterized these mice and have shown that their skin serves as an excellent target for CD8+ T cells from OVA‐specific T cell receptor Tg (OT‐I) mice. When the K14 OVA transgenic mice are crossed with the OT‐I mice they no longer serve as targets for the OT‐I CD8+ T cells from the OT‐I mice. This paradox is due to peripheral tolerance that is exhibited by the double Tg mice. I will discuss these two models and describe studies that are attempting to determine the mechanism of this peripheral tolerance.