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Cutaneous reactions from non‐steroidal anti‐inflammatory drugs: follow‐up of 4 years
Author(s) -
Galindo Esther Cuerda,
Buján J Goday,
Jorge B Fernández,
Lozano J Rodríguez,
Fonseca E
Publication year - 2004
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.0105-1873.2004.0309fx.x
Subject(s) - piroxicam , ketoprofen , medicine , patch test , dermatology , contact dermatitis , drug reaction , meloxicam , incidence (geometry) , allergic contact dermatitis , phenylbutazone , drug , allergy , anesthesia , pharmacology , immunology , physics , alternative medicine , pathology , optics
Cutaneous reactions due to use of non‐steroidal anti‐inflammatory drugs (NSAID) are frequently described. In the Contact Unit from the Department of Dermatology of Juan Canalejo Hospital, we compiled all cases studied during 4 years (from 2000 to 2003) to analyze the incidence, frequency and type of reactions derived from NSAIDs use. Material and methods: We used a NAIDs battery (Aristegui lab.Ò) on 55 patients with clinical suspicion of adverse reaction from NSAIDs. We performed epicutaneous study on 17 and additional photoallergic study, after UVA irradiation (from 5 to 7,5 J/cm 2 ), on 38 cases. In some cases we patched the drug used by patient as is and/or the active substance provided by the laboratory if it was not included on NSAIDs battery. Readings were done following ICDRG criteria at 48 and 96 hours on patch tests and 24 and 72 hours on photopatch tests. Healthy controls were patched. Results: 22 patients showed positive test: 15 cases were diagnosed as photoallergic dermatitis (etofenamate 5; dexketoprofen 4; ketoprofen 3; piroxicam 2; diclophenac 2 and aceclophenac 1). Five cases were explained as allergic contact dermatitis (etofenamate 2; fepradinol 2 and phenylbutazone 1) and two cases of fixed drug eruption from piroxicam were found. Conclusion: In this study we observed that cutaneous reactions due to ketoprofen and piroxicam are still high. It is important to note the high incidence of allergic and photoallergic reactions from dexketoprofen, a recently introduced NSAID, reporting always a cross reaction between ketoprofen and dexketoprofen.