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Sensitizing capacity and cross‐reactivity of phenyl glycidyl ether
Author(s) -
Pontén Ann,
Zimerson E,
Bruze M
Publication year - 2004
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.0105-1873.2004.0309df.x
Subject(s) - diglycidyl ether , epoxy , bisphenol a , chemistry , sensitization , bisphenol , reactivity (psychology) , ether , polymer chemistry , organic chemistry , immunology , medicine , pathology , alternative medicine
Phenyl glycidyl ether (PGE) is an aromatic reactive diluent used in epoxy resin systems. The sensitizing capacity of PGE, as well as the cross‐reactivity between PGE and the most important contact allergens in epoxy resins based on bisphenol A and bisphenol F, i.e. diglycidyl ether of bisphenol A (DGEBA) and the 3 isomers of diglycidyl ether of bisphenol F (p,p′‐DGEBF, o,p′‐DGEBF, and o,o′‐DGEBF), were investigated in a guinea pig maximization test (GPMT). Statistical significance was calculated with one‐sided Fisher’s exact test. PGE was found to be a strong sensitizer (24/24 sensitized animals, p < 0.001). Induction with DGEBA resulted in a statistically significant number of animals reacting to PGE (p = 0.006), but when induced with PGE, the animals did not react significantly to DGEBA. When induced with PGE, significant numbers of animals reacted to p,p′‐DGEBF (13/24 animals, p = 0.0011) and o,p′‐DGEBF (11/24 animals, p = 0.004). Induction with p,p′‐DGEBF and o,p′‐DGEBF resulted in a high number of reacting animals when tested with PGE (23/24 animals, p < 0.001 for both isomers). No statistically significant cross‐reactivity between PGE and o,o′‐DGEBF was found.Conclusion:According to our results in the GPMT, sensitization to DGEBA, which is the main constituent in the most common epoxy resin, may result in contact allergy to PGE, whereas sensitization to PGE seldom causes contact allergy to DGEBA. Sensitization to PGE may cause contact allergy to epoxy resins based on bisphenol F.