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FS09.4
Methyldibromo glutaronitrile in leave‐on products
Author(s) -
Pedersen Line Kynemund,
Agner T,
Held E,
Duus J Johansen
Publication year - 2004
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.0105-1873.2004.0309cg.x
Subject(s) - contact allergy , allergy , medicine , skin reaction , contact dermatitis , allergic reaction , patch test , allergic contact dermatitis , patch testing , dermatology , surgery , immunology
The rapidly increasing frequency of contact allergy to methyldibromo glutaronitrile (MDBGN) is of concern. This study investigates the allergic response elicited in pre‐sensitised individuals from exposure to a leave‐on product preserved with 50 or 100 ppm MDBGN. Material and methods: Eighteen volunteers with contact allergy to MDBGN and 10 healthy controls were exposed to repeated open allication tests (ROAT) with two moisturisers with a high and a low lipid content, respectively, both containing MDBGN in a concentration of 50 ppm. The ROATs were performed on the left and the right side of the neck for 14 days, or until a positive reaction was seen. If a positive reaction did not develop within the first 14 days the application with analogous moisturisers containing 100 ppm MDBGN continued for further 14 days. Results: Eleven (61.1%) developed dermatitis on the test area, and 10 (55.5%) developed a positive reaction to 50 ppm moisturiser. Reactions to the low‐ moisturiser were the most frequent. the controls all had negative ROATs. Conclusion: A concentration of 50 ppm MDBGN in a leave‐on product was found to elicit an allergic reaction in more than half of sensitised individuals when applied on the neck.