Premium
FS09.3
Can Flutivate® cream be safely used in formaldehyde‐allergic patients?
Author(s) -
Isaksson Marléne,
Gruvberger B,
Goon A TJ,
Bruze M
Publication year - 2004
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.0105-1873.2004.0309cf.x
Subject(s) - formaldehyde , medicine , allergic dermatitis , allergic contact dermatitis , preservative , allergy , dermatology , potency , immunology , food science , chemistry , organic chemistry , in vitro , biochemistry
Objectives: To study the healing time of an experimental eczema treated with Flutivate® cream, a potent corticosteroid containing a formaldehyde releasing preservative, in patients allergic to formaldehyde and controls not allergic to formaldehyde. Methods: 24 individuals allergic to nickel, 7 of whom were also allergic to formaldehyde, had a nickel‐allergic contact dermatitis experimentally induced on both upper arms. The dermatitis was treated twice daily for a maximum of 3 weeks or until healing with either Flutivate® cream or Betnovate® cream, a corticosteroid with the same potency but containing another preservative, which was tolerated by all 24 study persons. The study was double‐blind and randomized. Results: In 12/17 controls (71%) the nickel‐allergic contact dermatitis healed completely when treated with Flutivate® cream compared to 2/7 formaldehyde‐allergic patients (29%)(p < 0.05). Conclusion: Flutivate® cream should not be used by individuals allergic to formaldehyde.