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New standardized allergens: the experimental TRUE Test® Panel
Author(s) -
Hoeck Ulla,
Lehmann S,
Bjarnoe H,
Meldgaard J,
Laugesen L Holm
Publication year - 2004
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.0105-1873.2004.0309bi.x
Subject(s) - patch test , potassium dichromate , allergic contact dermatitis , budesonide , contact allergy , preservative , allergy , chemistry , dermatology , contact dermatitis , medicine , immunology , surgery , corticosteroid , organic chemistry
TRUE Test® is the only standardized patch test system for the diagnosis of allergic contact dermatitis based on 24 fully stable and reproducible formulations. New standardized patches are in process of development for TRUE Test® Panel 3. The allergens chosen are well‐known sensitizers and include preservatives, steroids, metals and others. 14 new patches are included in an Experimental panel which is tested in several European clinics. 11 of the patches contain new allergens while 3 patches consist of improved TRUE Test® formulations with Neomycine sulphate, Fragrance mix and Potassium dichromate. A number of the patches from the Experimental panel will be selected for TRUE Test® Panel 3. The overall purpose with pharmaceutical development of patch test materials for TRUE Test® is to obtain a precise dose, bioavailability and stability in every single patch. The patches have to be chemically stable for at least 2 years at refrigerated temperature. The selected preservatives on the Experimental panel are Methyldibromoglutaronitrile, Germall 115, Germall II and Bronopol. All 4 patches have proven to be difficult to stabilize because of the natural reactivity of the allergenic substances. The steroids chosen are Budesonide, Tixocortol‐21‐pivalate and Hydrocortisone‐17‐butyrate. All 3 steroids are stable in TRUE Test® formulations. Other allergens on the Experimental panel are Ammoniated Mercury, Goldsodiumthiosulphate, Parthenolide and Disperse blue 106, where the latter consists of a complex mixture. Chemical stabilization of the patches as well as clinical studies will be presented.