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Patch tests with gluten and gliadin in children with coeliac disease
Author(s) -
Giusti Francesca,
Amarri S,
Seidenari S
Publication year - 2004
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.0105-1873.2004.0309ay.x
Subject(s) - gliadin , coeliac disease , gluten , medicine , atopy , immunology , gastroenterology , gluten free , disease , immunopathology , pathology
Atopy patch tests (ATPs) are believed to be a useful diagnostic procedure for atopic dermatitis (AD), aiming at the detection of delayed reactions to aeroallergens and food allergens. Our aim was to investigate immune responses to gluten and gliadin in children affected by coeliac disease by performing APTs, and to compare these data to the ones observed in AD patients. 31 children, 15 males and 16 females (mean age ± s.d. = 5,5 ± 3,8 years) affected by coeliac disease underwent APTs with gluten and gliadin. Among these, 15 children were on gluten‐free diet at the moment of our examination and 3 patients were affected by AD. 83 AD children not affected by celiac disease, were used as controls. 19,4% and 12,9% of children with coeliac disease proved positive to APTs with gluten and gliadin, respectively. No difference in the frequency and intensity of APT responses were present between the patients on gluten‐free diet and the children not on diet. Among AD patients 12% reacted to gluten, whereas no positive reactions to gliadin were observed. Going on these findings, the cellular‐mediated reactivity to gliadin in patients with coeliac disease may show a clinical expression by positive APT reactions to gliadin. These represent a specific finding in subjects with coeliac disease when compared to AD children.