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Occupational contact dermatitis from methylisothiazolinone
Author(s) -
Isaksson Marléne,
Gruvberger B,
Bruze M
Publication year - 2004
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.0105-1873.2004.0309ar.x
Subject(s) - medicine , patch test , dermatology , preservative , contact dermatitis , allergic contact dermatitis , biocide , sensitization , allergy , pathology , chemistry , organic chemistry , immunology
Background: The preservative methylchloroisothiazolinone/methylisothiazolinone (MCI/MI) has been used extensively in various products since the 1980s. Recently, a biocide containing only MI and not MCI has been launched on the Swedish market for use in industrial settings, paints and glues. Objectives: To describe sensitization to the unchlorinated isothiazolinone 2‐methyl‐4‐isothiazolin‐3‐one (MI) in 2 workers, a technician after a chemical burn and a painter, both exposed to a preservative containing MI. Methods: Patch testing with serial dilutions of MCI/MI, MCI, MI, 2‐n‐octyl‐4‐isothiazolin‐3‐one (OIT) and a commercial preservative containing MI in the 2 workers. Results: The patients reacted positively to MCI/MI and to the separate active ingredients (MCI, MI). The patch test reactivity to MI was higher than the reactivity to MCI, which is a reversed pattern to what is usually seen in patients sensitized to MCI/MI. Both patients also had positive test reactions to OIT. Conclusion: MI may sensitize on it’s own, and in patients allergic to MI, cross‐reactions are also seen to MCI.