Premium
Human scalp irritation compared to that of the arm and back
Author(s) -
Zhai Hongbo,
Fautz Rolf,
Fuchs Anne,
Bhandarkar Sulochana,
Maibach Howard I.
Publication year - 2004
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.0105-1873.2004.00439.x
Subject(s) - irritation , pipette , socks , scalp , biomedical engineering , medicine , volunteer , surgery , chromatography , chemistry , dermatology , materials science , composite material , agronomy , immunology , biology
Large‐scale data comparing reactions to surfactants between scalp and back and arm are lacking. The sensitivity of responses between scalp and back and arm were explored utilizing an open‐application model for testing the potential irritancy of sodium lauryl sulphate (SLS). 10 bald male Caucasians (mean age 56 ± 9 years) were enrolled. We conducted 5 successive washings: for each wash, the technician pipetted 1 ml of 20% SLS solution into a glass cylinder placed on the designated area with hand pressure that prevented the cylinder leaking. The test area was then rubbed with a Teflon Policeman scrubber for 1 min. Post scrubbing, the solution was absorbed dry with a plastic pipette and blotted by gently applying paper tissues. After a 5‐min rest, the procedure was repeated for 4 more times for a total of 5 times. Skin‐irritancy assessments by visual scoring and instrumental measurements were made at 30 min and 24 h thereafter and squamometry at the end of last washing. Results indicated that most param‐ eters revealed that the back was most sensitive to the SLS challenge. Thus, these data support the current standard skin‐compatibility testing procedure, employing the back for potential irritation testing of hair care products.