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P06
Axillary irritation: methods of assessment
Author(s) -
Peters L,
Marriott Marie,
Basketter DA
Publication year - 2004
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.0105-1873.2004.00309en.x
Subject(s) - axilla , irritation , patch testing , skin irritation , patch test , medicine , dermatology , allergic contact dermatitis , surgery , contact dermatitis , allergy , immunology , cancer , breast cancer
Axillary dermatitis can be associated with the use of underarm products. However the unique physiology of this region makes assessment of irritation problematic. Furthermore, given the type of products used in the underarm, the friction and occlusive nature of the site, it is necessary not only to concentrate on the area of application ie the area of hair growth, but also to examine the periphery. There is evidence that products tend to move to this area during the day possibly as a consequence of axillary physiology and mechanical effects. Consequent upon these various factors, predicting axillary irritation from acute patch tests on back or arm skin is problematic. In a recent comparison, we found that where approximately 10% of panellists reacted to a formulation by patch test, 50% developed axillary reactions during a 21 day use test. In addition, not all those who reacted in the patch test reacted in the axilla. Predicting axillary effects from repeated open tests seems better but still has challenges; currently we are assessing alternative strategies to permit rapid identification of potential issues without recourse to extended in use tests.