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Photoallergic contact dermatitis from ketoprofen in Southern Sweden
Author(s) -
Hindsén Monica,
Zimerson E,
Bruze M
Publication year - 2004
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.0105-1873.2004.00309eb.x
Subject(s) - ketoprofen , dermatology , contact dermatitis , patch test , chemistry , medicine , allergy , pharmacology , immunology
Objective: In Sweden ketoprofen has been available for topical applications since 1995. Photoallergic contact dermatitis from ketoprofen has been reported since almost 20 years. Photoallergic contact dermatitis from ketoprofen‐containing topical treatment usually includes severe eczematous reactions. Ketoprofen is an NSAID derived from propionic acid. Ketoprofen, fenofibrate and benzophenones are structurally similar. Methods: Photopatch testing and patch testing with 2 standard series, the ketoprofen‐containing gels and their ingredients, fenofibrate and benzophenones. Results: During the last year 35 patients have been photopatch tested with ketoprofen with very strong photopatch test reactions. 26 patients also had positive reactions to fentichlor. 27 of the ketoprofen – photoallergic patients had also been photopatch tested with fenofibrate, 17 had positive reactions. 21 had positive reactions to balsam of Peru and 13 to fragrance mix. Conclusion: Ketoprofen is a strong photosensitizer.