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Impact of tobacco smoking on platelet function in apheresis products in vitro
Author(s) -
Scheinichen D.,
Heuft H.G.,
Renken C.,
Jüttner B.,
Jaeger K.,
Schürholz T.,
Blasczyk R.,
Piepenbrock S.,
Elsner H.A.
Publication year - 2004
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.0042-9007.2004.00507.x
Subject(s) - apheresis , platelet , medicine , in vitro , immunology , chemistry , biochemistry
Background and Objectives The aim of this study was to analyse the platelet function, over a 5‐day time‐period, of apheresis‐derived platelet concentrates obtained from smokers and non‐smokers. Materials and Methods Smoker and non‐smoker plateletpheresis products were investigated on days 1, 3 and 5 of storage. Receptor expression (as evaluated by flow cytometry) and the platelet aggregation response were measured. Results There was only a slight loss of platelet function in apheresis products from smokers compared to non‐smokers. Conclusions Smoking does not significantly change the quality of platelet preparations. The current practice, of not to exclude smokers from platelet donation, can be continued.