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CD4 + CD25 + Treg: divide and rule?
Author(s) -
Walker Lucy S. K.
Publication year - 2004
Publication title -
immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.297
H-Index - 133
eISSN - 1365-2567
pISSN - 0019-2805
DOI - 10.1111/j.0019-2805.2003.01788.x
Subject(s) - treg cell , il 2 receptor , homeostasis , function (biology) , biology , immunology , microbiology and biotechnology , t cell , immune system
Summary Research on CD4 + CD25 + regulatory T cells (Treg) has gathered momentum over the last five years but many aspects of their fundamental biology remain elusive. Treg have been considered to be ‘naturally anergic’ based on their failure to proliferate in response to T‐cell receptor ligation in vitro . Several recent studies challenge this view and demonstrate a robust proliferative capacity for CD25 + cells. The significance of this finding for Treg homeostasis and function is considered below.