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LINKAGE BETWEEN NUCLEAR AND MITOCHONDRIAL DNA SEQUENCES IN AVIAN MALARIA PARASITES: MULTIPLE CASES OF CRYPTIC SPECIATION?
Author(s) -
Bensch Staffan,
PéarezTris Javier,
Waldenströum Jonas,
Hellgren Olof
Publication year - 2004
Publication title -
evolution
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.84
H-Index - 199
eISSN - 1558-5646
pISSN - 0014-3820
DOI - 10.1111/j.0014-3820.2004.tb01742.x
Subject(s) - biology , mitochondrial dna , avian malaria , parasite hosting , cytochrome b , haemoproteus , lineage (genetic) , evolutionary biology , nuclear gene , genetics , plasmodium (life cycle) , phylogenetics , locus (genetics) , gene , malaria , plasmodium falciparum , immunology , world wide web , computer science , gametocyte
Abstract Analyses of mitochondrial cytochrome b diversity among avian blood parasites of the genera Haemoproteus and Plasmodium suggest that there might be as many lineages of parasites as there are species of birds. This is in sharp contrast to the approximately 175 parasite species described by traditional methods based on morphology using light microscopy. Until now it has not been clear to what extent parasite mitochondrial DNA lineage diversity reflects intra‐ or interspecific variation. We have sequenced part of a fast‐evolving nuclear gene, dihydrofolate reductase‐thymidylate synthase (DHFR‐TS), and demonstrate that most of the parasite mitochondrial DNA lineages are associated with unique gene copies at this locus. Although these parasite lineages sometimes coexist in the same host individual, they apparently do not recombine and could therefore be considered as functionally distinct evolutionary entities, with independent evolutionary potential. Studies examining parasite virulence and host immune systems must consider this remarkable diversity of avian malaria parasites.