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TOWARD A REALISTIC MODEL OF MUTATIONS AFFECTING FITNESS
Author(s) -
Keightley Peter D.,
Lynch Michael
Publication year - 2003
Publication title -
evolution
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.84
H-Index - 199
eISSN - 1558-5646
pISSN - 0014-3820
DOI - 10.1111/j.0014-3820.2003.tb01561.x
Subject(s) - biology , mutation , arabidopsis , mutation accumulation , genetics , evolutionary biology , mutation rate , gene , mutant
Analysis of a recent mutation accumulation (MA) experiment has led to the suggestion that as many as one‐half of spontaneous mutations in Arabidopsis are advantageous for fitness. We evaluate this in the light of data from other MA experiments, along with molecular evidence, that suggest the vast majority of new mutations are deleterious.