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EFFECT OF DELETERIOUS MUTATION‐ACCUMULATION ON THE FITNESS OF RNA BACTERIOPHAGE MS2
Author(s) -
Penta Marcos,
Elena Santiago F.,
Moya Andres
Publication year - 2000
Publication title -
evolution
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.84
H-Index - 199
eISSN - 1558-5646
pISSN - 0014-3820
DOI - 10.1111/j.0014-3820.2000.tb00069.x
Subject(s) - biology , bacteriophage , mutation rate , mutation accumulation , rna , mutation , genetics , selection (genetic algorithm) , experimental evolution , genetic fitness , negative selection , evolutionary biology , gene , genome , escherichia coli , artificial intelligence , computer science
.— RNA viruses show the highest mutation rate in nautre. It has been extensively demonstrated that, in the absence of purifying selection, RNA viruses accumulate deleterious mutations at a high rate. However, the parameters describing this accumulation are, in general, poorly understood. The present study reports evidences for fitness declines by the accumulation of deleterious mutations in the bacteriophage MS2. We estimated the rate of fitness decline to be as high as 16% per bottleneck transfer. In addition, our results agree with an additive model of fitness effects.