Premium
Surgery for Epilepsy Due to Cortical Malformations: Ten‐year Follow‐up
Author(s) -
Hamiwka Lorie,
Jayakar Prasanna,
Resnick Trevor,
Morrison Glenn,
Ragheb John,
Dean Patricia,
Dunoyer Catalina,
Duchowny Michael
Publication year - 2005
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1111/j.0013-9580.2005.52504.x
Subject(s) - cortical dysplasia , epilepsy , medicine , dysplasia , surgery , epilepsy surgery , cohort , central nervous system disease , pediatrics , el niño , pathology , psychiatry
Summary: Children with malformations of cortical development represent a significant proportion of pediatric epilepsy surgery candidates. From a cohort of 40 children operated on between 1980 and 1992 with malformation of cortical development, 38 were alive and had data 10 years after surgery. Age at surgery ranged from 6 months to 18 years (mean, 9.6 years). Thirty‐six had partial seizures, and two had infantile spasms; 20 were nonlesional. Pathologic diagnoses were cortical dysplasia (n = 31) and developmental tumor (n = 7). At 10‐year follow‐up, 15 (40%) were seizure free, 10 (26%) had >90% seizure reduction, and 13 (34%) were improved or unchanged. Children seizure free at two‐year follow‐up were likely to remain seizure free. Ten‐year seizure freedom was 72% in children with developmental tumors and 32% in the cortical dysplasia group. Complete resection was statistically significant for favorable outcome, and no patient with an incomplete resection was seizure free.