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Spasmodic Dysphonia Induced by Valproic Acid
Author(s) -
Oh Jeeyoung,
Park Kee Duk,
Cho Hyun Ji,
Choi Kyoung Gyu,
Jung Sung Min
Publication year - 2004
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1111/j.0013-9580.2004.69603.x
Subject(s) - valproic acid , parkinsonism , basal ganglia , anticonvulsant , spasmodic dysphonia , neuroscience , medicine , pharmacology , anesthesia , epilepsy , psychology , central nervous system , botulinum toxin , disease
Summary: Valproic acid (VPA) is an antiepileptic drug (AED) with a broad spectrum of actions. The mechanisms that underlie VPA effects are not clearly elucidated, but may include enhancement of γ‐aminobutyric acid (GABA)‐mediated inhibition by increasing cerebral GABA levels. Transient extrapyramidal symptoms like parkinsonism have been reported with VPA treatment (1). The precise mechanism of these complications is not clear, although perturbations in basal ganglia neurotransmitters have been suggested. We experienced one case of spasmodic dysphonia in the course of treatment with VPA, which has not been described previously.